Research Articles
CRISPR Beyond the Lab: Revolutionizing Interdisciplinary Biomedical Research and Drug Development
This comprehensive article explores the transformative impact of CRISPR gene editing across the interdisciplinary biomedical research landscape.
CRISPR-Cas9 Fidelity Across Genomes: A Comparative Analysis of Cloning Efficiency, Off-Target Effects, and Host-Specific Biases
This comprehensive review synthesizes the latest research on how host genome context influences CRISPR-Cas9 cloning fidelity.
Beyond PCR: How CRISPR-Cas9 Direct Cloning is Revolutionizing Biosynthetic Gene Cluster Discovery and Drug Development
This article provides a comprehensive guide for researchers on the application of CRISPR-Cas9 for the direct cloning of biosynthetic gene clusters (BGCs).
Humid Conditions and CO2 Capture: A Critical Comparison of Material Performance for Research and Biomedical Applications
This article provides a comprehensive analysis of CO2 capture material performance under humid conditions, crucial for realistic environmental and biomedical applications.
Mastering BGC Cloning: A Comprehensive Guide to the CAPTURE Method for Natural Product Discovery
This guide provides a detailed exploration of the CAPTURE (Cas12a-Assisted Precise Targeted Cloning Using in vivo CRE) method for Bacterial Genomic Cluster (BGC) cloning, a revolutionary technique in natural product...
Brownian Motion in Molecular Machines: From Thermal Noise to Biological Function and Therapeutic Targeting
This article provides a comprehensive analysis of Brownian motion's multifaceted role in molecular machines, targeting researchers and drug development professionals.
Genetic Algorithms vs. Reinforcement Learning: A 2024 Benchmark for AI-Driven Molecular Optimization in Drug Discovery
This comprehensive analysis benchmarks Genetic Algorithms (GAs) against Reinforcement Learning (RL) for the critical task of molecular optimization in drug discovery.
Beyond the Baseline: A Comprehensive Benchmark of Modern AI Algorithms for Penalized logP Molecular Optimization
Penalized logP has become a critical benchmark for evaluating AI-driven molecular optimization algorithms in drug discovery.
Multi-Property Molecular Optimization: A Comparative Benchmark Study of STONED, MolFinder, and GB-GA-P
This article presents a detailed comparative analysis of three leading computational approaches for multi-property molecular optimization in drug discovery: the STochastic Exploration of Chemical Space (STONED) algorithm, the fragment-based MolFinder...
Bayesian Optimization in Molecular Latent Space: Accelerating Drug Discovery with AI-Driven Design
This article provides a comprehensive guide to Bayesian Optimization (BO) within molecular latent spaces for researchers and drug development professionals.